
M_Physiology
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Publications
Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis.
Current biology : CB
Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors.
Science advances
Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing.
Nature communications
Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing.
bioRxiv : the preprint server for biology
Institutional Conversion to Energy-Efficient Ultra-Low Freezers Decreases Carbon Footprint and Reduces Energy Costs.
Biopreservation and biobanking
Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein.
The Journal of biological chemistry
The molecular mechanisms of human separase regulation.
Biochemical Society transactions
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.
The Journal of biological chemistry
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.
bioRxiv : the preprint server for biology
Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C.
Nature communications
Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription.
Current biology : CB
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.
Molecular cell
Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein.
bioRxiv : the preprint server for biology
Polyanions provide selective control of APC/C interactions with the activator subunit.
Nature communications
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.
Nature communications
The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
The Journal of biological chemistry
Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.
Current biology : CB
Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.
Molecular cell
Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development.
Developmental cell
An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.
The Journal of biological chemistry
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.
The Journal of cell biology
Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis.
Journal of cell science
Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate.
Biology open
Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.
Current biology : CB
Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.
Journal of cell science
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology.
Journal of the American Chemical Society
The D box meets its match.
Molecular cell
Sequential primed kinases create a damage-responsive phosphodegron on Eco1.
Nature structural & molecular biology
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.
Molecular cell
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.
Developmental cell
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.
Current biology : CB
Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes.
The Journal of biological chemistry
Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.
Molecular cell
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science (New York, N.Y.)
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.
Molecular cell
Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.
Molecular cell
Mechanisms of ubiquitin transfer by the anaphase-promoting complex.
Journal of biology
The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.
Molecular biology of the cell
Cyclin-specific control of ribosomal DNA segregation.
Molecular and cellular biology
Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.
Molecular cell
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.
Proceedings of the National Academy of Sciences of the United States of America
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Chemistry & biology
Finishing mitosis, one step at a time.
Nature reviews. Molecular cell biology
Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.
Molecular biology of the cell
The role of self-association in Fin1 function on the mitotic spindle.
The Journal of biological chemistry
A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.
The Journal of biological chemistry
Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
Nature cell biology
An architectural map of the anaphase-promoting complex.
Genes & development
The APC subunit Doc1 promotes recognition of the substrate destruction box.
Current biology : CB
Enzymology of the anaphase-promoting complex.
Methods in enzymology
The Doc1 subunit is a processivity factor for the anaphase-promoting complex.
Nature cell biology
Inhibitor scaffolds as new allele specific kinase substrates.
Journal of the American Chemical Society
Oscillation sensation.
Nature
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